I have been involved in biology of aging research since 2000. I have a degree in Biochemistry from Trinity College Dublin, Ireland and a PhD in Biochemistry from University College Dublin, Ireland. I received post-doctoral training at Harvard Medical School, Boston, MA, and at the University of Wisconsin Madison, WI, USA. The goal of my work is to understand why aging increases disease vulnerability. My lab works with mice and nonhuman primates to uncover mechanisms of caloric restriction (CR), a dietary intervention that delays aging and the onset of numerous age-related diseases and disorders. Investigations include analysis of gene expression, metabolomics, proteomics and cell signaling in response to CR. Molecular leads revealed by these studies are followed up in cell culture models using genetic and pharmacological approaches.
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